Functional genomics I Introduction and designing experiments. Open Tree arrow-right-1 Course overview Search within this course Taking this course What is genomics? What is functional genomics? In contrast, functional genomics focuses on the function and property. Overview and Key Difference 2. What is Structural Genomics 3. What is Functional Genomics 4. Similarities Between Structural and Functional Genomics 5. Structural genomics is the studying of the physical nature of the genome. Therefore, structural genomics mainly concerns the sequencing and mapping of genomes.
The complete sequence of genomes or the complete set of proteins in an organism is determined by structural genomics. Genetic and physical maps are constructed in structural genomics. Moreover, structural genomics also involves sequencing of the genome and determination of the three-dimensional structure of each protein coded by genes of the genome.
Functional genomics is a branch of genomics which deals with the expression of genes and their functions. It also concerns the pattern of gene expression and metabolic pathways. The 3D information allows protein sequences predicted from DNA sequences to be classified into broad groups, according to the overall 'fold', or 3D shape, of the protein.
Structural information can be used to predict the preferred substrate of a protein, and thereby greatly enhance the accurate annotation of the corresponding gene. Furthermore, it will enable the effects of amino acid substitutions in enzymes to be better understood with respect to enzyme function and could thereby provide insights into natural variation in genes.
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